Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery

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Persistent microbial dysbiosis in preterm premature rupture of membranes from onset until delivery.

Background. Preterm Premature Rupture of Membranes (PPROM) is a major leading cause of preterm births. While the cause for PPROM remains unidentified, it is anticipated to be due to subclinical infection, since a large proportion of PPROM patients display signs of chorioamnionitis. Since subclinical infections can be facilitated by dysbiosis, our goal was to characterize the vaginal microbiome ...

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Outcome of preterm premature rupture of membranes.

OBJECTIVE To study the incidence and outcome of preterm premature rupture of membranes (PPROM). DESIGN Cross-sectional study. SETTING Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University. SUBJECTS Ninety five PPROM women who were expectant management and delivered between January 1, 1997 and December 31, 1997. RESULTS The incidence of PPROM was 7.2 per ...

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Antibiotics for preterm premature rupture of membranes.

OBJECTIVES The aim of the review was to evaluate the effectiveness and the immediate and long-term safety of the effects of administering antibiotics to women with preterm prelabour rupture of membranes on maternal infectious morbidity, fetal and neonatal morbidity and mortality, and longer term childhood development. SEARCH STRATEGY All randomized trials identified using the search strategy ...

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Antenatal corticosteroids in preterm premature rupture of membranes.

It is clear that there is no unequivocal indication for the use of antenatal corticosteroids in the preterm gestation with PROM. Extrapolating the effects seen in gestations with intact membranes, however, there are potential benefits in reduction of neonatal respiratory disease and intracranial hemorrhage at the expense of increased risks of maternal postpartum infection. Because the lifetime ...

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Cord blood cytokine levels in focal early-onset neonatal infection after preterm premature rupture of membranes.

This study aimed to evaluate the levels of pro- and anti-inflammatory cytokines in umbilical cord blood of preterm neonates who developed focal early-onset infection (EOI) after preterm premature rupture of membranes (PPROM). This is a prospective study conducted on 46 preterm infants from mothers with PPROM. The cytokines were measure by flow cytometry. Newborns were classified into two groups...

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ژورنال

عنوان ژورنال: PeerJ

سال: 2015

ISSN: 2167-8359

DOI: 10.7717/peerj.1398